Evaluating Existing Processes for Uptake of Scientific Evidence on AMR

Antimicrobial resistance (AMR) represents one of the most pressing global health challenges, yet translating scientific evidence into effective policy has proven slow, uneven, and fragmented across contexts. To inform the design of a proposed Independent Panel for Evidence for Action (IPEA) against AMR, this paper reviews lessons from past and ongoing efforts to bridge the evidence-policy gap in AMR and related fields. Using desk research and 15 key informant interviews with AMR experts across disciplines and geographies, we applied the Knowledge-to-Action framework to examine challenges and opportunities in evidence translation. Our analysis highlights persistent gaps in knowledge creation, uneven investment in evidence synthesis, and limited downstream uptake mechanisms, particularly in low- and middle-income countries and non-human health sectors. Case studies of the Evidence-Informed Policy Network and Regional AMR Data Analysis for Advocacy, Response and Policy collaboration and the US Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria demonstrate the importance of local capacity building, multisectoral collaboration, sustained governance, and clear policy outputs. We recommend that the IPEA prioritize equitable One Health engagement, modular and context-specific policy guidance, stronger linkages between upstream evidence generation and downstream implementation, and coordination with existing initiatives to avoid duplication. By embedding these lessons, the IPEA can accelerate the uptake of AMR evidence into actionable policies, strengthen global governance, and help preserve the effectiveness of antimicrobials for future generations.